Studying the gene expression profiles of organisms at various ages is a powerful tool for longevity research. It can demonstrate how an organism changes with time from a gene network regulatory perspective. Gene expression analysis can also provide insight into how the organism reacts to the accumulation of damage with time.

One particularly useful application of gene expression is in stem cell research. It is known that stem cells show signs of aging and that their numbers and effectiveness decline with age.

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Gene Expression Papers Related to Aging

• AGEMAP: A Gene Expression Database for Aging in Mice Zahn JM, Poosala S, Owen AB, Ingram DK, Lustig A, et al. PLoS Genetics Vol. 3, No. 11, e201 doi:10.1371/journal.pgen.0030201
• (PDF) Stuart K. Kim - Genome-wide Views of Aging (Draft) (Date: 5/9/2007)

Stem Cells & Epigenetic Dysregulation

• Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation
• The role of DNA damage repair in aging of adult stem cells

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